β-Thalassemia: the Lebanese experience

Hematological malignancies complicating β-thalassemia syndromes: a single center experience

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hematological malignancies complicating β-thalassemia syndromes: a single center experience TO THE EDITOR: Only few reports have addressed the occurrence of hematological malignancies in patients suffering from β-thalassemia. We herein report two patients wi...

β-Thalassemia Intermedia in Northern Iraq: A Single Center Experience

To investigate the molecular basis of β -thalassemia intermedia in Northern Iraq and evaluate its management practices, a total of 74 patients from 51 families were enrolled. The patients were clinically and hematologically reevaluated, and had their β-thalassemia mutations characterized, as well as the number of α-globin genes and Xmn I (G)γ-158 (C>T) polymorphism studied. Out of 14 β-thalasse...

Gene Therapy for β - Thalassemia

Gene transfer for β-thalassemia requires gene transfer into hematopoietic stem cells using integrating vectors that direct regulated expression of β globin at therapeutic levels. Among integrating vectors, oncoretroviral vectors carrying the human βglobin gene and portions of the locus control region (LCR) have suffered from problems of vector instability, low titers and variable expression. In...

Ineffective Erythropoiesis in β-Thalassemia

In humans, β -thalassemia dyserythropoiesis is characterized by expansion of early erythroid precursors and erythroid progenitors and then ineffective erythropoiesis. This ineffective erythropoiesis is defined as a suboptimal production of mature erythrocytes originating from a proliferating pool of immature erythroblasts. It is characterized by (1) accelerated erythroid differentiation, (2) ma...

Genomic Study in β - Thalassemia